High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds.
Identifieur interne : 000483 ( Main/Exploration ); précédent : 000482; suivant : 000484High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds.
Auteurs : Kyeong-Ryeol Lee [Corée du Sud] ; Kyung-Hwan Kim [Corée du Sud] ; Jung Bong Kim [Corée du Sud] ; Seung-Bum Hong [Corée du Sud] ; Inhwa Jeon [Corée du Sud] ; Hyun Uk Kim [Corée du Sud] ; Myung Hee Lee [Corée du Sud] ; Jae Kwang Kim [Corée du Sud]Source :
- BMC plant biology [ 1471-2229 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Fatty Acids, Omega-3, Plant Oils, gamma-Linolenic Acid.
- metabolism : Perilla frutescens, Seeds.
- Plants, Genetically Modified.
Abstract
BACKGROUND
Polyunsaturated fatty acids such as linoleic acid (LA) and α-linolenic acid (ALA) are abundant in vegetable oils and are important for human health. In the body, LA and ALA are respectively converted to the omega-6 fatty acid γ-linolenic acid (GLA) and the omega-3 fatty acid stearidonic acid (SDA) by Δ6 desaturase (D6DES). Currently, dietary GLA and SDA are mainly obtained from marine organisms, but given their benefits to human health, many studies have aimed to enhance their accumulation in transgenic crops. Perilla frutescens (perilla) accumulates more ALA in its seed oil compared to other oilseed crops, making it a good candidate for the production of fatty acids via the fatty acid desaturase D6DES.
RESULTS
In this study, we cloned the D6DES gene from Phytophthora citrophthora and confirmed its function in budding yeast. We then transformed the functional D6DES gene under the control of the seed-specific vicilin promoter into the perilla cultivar Yeobsil. The resulting transgenic perilla seeds accumulated significant levels of GLA and SDA, as well as putative C18:2Δ
CONCLUSIONS
Thus, PcD6DES perilla plants may represent a feasible alternative to traditional marine sources for the production of omega-3 oil capsules and to evening primrose seed oil for GLA as health food. In addition, these plants can be used to create other transgenic lines harboring additional genes to produce other desirable fish-oil like oils.
DOI: 10.1186/s12870-019-1713-2
PubMed: 30935415
PubMed Central: PMC6444538
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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wicri:level="1"><nlm:affiliation>Department of Southern Area Crop Science, National Institute of Crop Science, Miryang, Gyeongsangnamdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Southern Area Crop Science, National Institute of Crop Science, Miryang, Gyeongsangnamdo</wicri:regionArea><wicri:noRegion>Gyeongsangnamdo</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jae Kwang" sort="Kim, Jae Kwang" uniqKey="Kim J" first="Jae Kwang" last="Kim">Jae Kwang Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Life Sciences, Incheon National University, Incheon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Life Sciences, Incheon National University, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30935415</idno><idno type="pmid">30935415</idno><idno type="doi">10.1186/s12870-019-1713-2</idno><idno type="pmc">PMC6444538</idno><idno type="wicri:Area/Main/Corpus">000511</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000511</idno><idno type="wicri:Area/Main/Curation">000511</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000511</idno><idno type="wicri:Area/Main/Exploration">000511</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds.</title><author><name sortKey="Lee, Kyeong Ryeol" sort="Lee, Kyeong Ryeol" uniqKey="Lee K" first="Kyeong-Ryeol" last="Lee">Kyeong-Ryeol Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo</wicri:regionArea><wicri:noRegion>Jeollabukdo</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Kyung Hwan" sort="Kim, Kyung Hwan" uniqKey="Kim K" first="Kyung-Hwan" last="Kim">Kyung-Hwan Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea. biopiakim@korea.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo</wicri:regionArea><wicri:noRegion>Jeollabukdo</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jung Bong" sort="Kim, Jung Bong" uniqKey="Kim J" first="Jung Bong" last="Kim">Jung Bong Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agro-food Resources, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Agro-food Resources, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo</wicri:regionArea><wicri:noRegion>Jeollabukdo</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Seung Bum" sort="Hong, Seung Bum" uniqKey="Hong S" first="Seung-Bum" last="Hong">Seung-Bum Hong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural Biology, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Agricultural Biology, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo</wicri:regionArea><wicri:noRegion>Jeollabukdo</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Inhwa" sort="Jeon, Inhwa" uniqKey="Jeon I" first="Inhwa" last="Jeon">Inhwa Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo</wicri:regionArea><wicri:noRegion>Jeollabukdo</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hyun Uk" sort="Kim, Hyun Uk" uniqKey="Kim H" first="Hyun Uk" last="Kim">Hyun Uk Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioindustry and Bioresource Engineering, Plant Engineering Research Institute, Sejong University, Seoul, 05006, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Bioindustry and Bioresource Engineering, Plant Engineering Research Institute, Sejong University, Seoul, 05006</wicri:regionArea><wicri:noRegion>05006</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Myung Hee" sort="Lee, Myung Hee" uniqKey="Lee M" first="Myung Hee" last="Lee">Myung Hee Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Southern Area Crop Science, National Institute of Crop Science, Miryang, Gyeongsangnamdo, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Southern Area Crop Science, National Institute of Crop Science, Miryang, Gyeongsangnamdo</wicri:regionArea><wicri:noRegion>Gyeongsangnamdo</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jae Kwang" sort="Kim, Jae Kwang" uniqKey="Kim J" first="Jae Kwang" last="Kim">Jae Kwang Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Life Sciences, Incheon National University, Incheon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Life Sciences, Incheon National University, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC plant biology</title><idno type="eISSN">1471-2229</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fatty Acids, Omega-3 (metabolism)</term><term>Perilla frutescens (metabolism)</term><term>Plant Oils (metabolism)</term><term>Plants, Genetically Modified (MeSH)</term><term>Seeds (metabolism)</term><term>gamma-Linolenic Acid (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide gamma linolénique (métabolisme)</term><term>Acides gras omega-3 (métabolisme)</term><term>Graines (métabolisme)</term><term>Huiles végétales (métabolisme)</term><term>Perilla frutescens (métabolisme)</term><term>Végétaux génétiquement modifiés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids, Omega-3</term><term>Plant Oils</term><term>gamma-Linolenic Acid</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Perilla frutescens</term><term>Seeds</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide gamma linolénique</term><term>Acides gras omega-3</term><term>Graines</term><term>Huiles végétales</term><term>Perilla frutescens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Plants, Genetically Modified</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Végétaux génétiquement modifiés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Polyunsaturated fatty acids such as linoleic acid (LA) and α-linolenic acid (ALA) are abundant in vegetable oils and are important for human health. In the body, LA and ALA are respectively converted to the omega-6 fatty acid γ-linolenic acid (GLA) and the omega-3 fatty acid stearidonic acid (SDA) by Δ6 desaturase (D6DES). Currently, dietary GLA and SDA are mainly obtained from marine organisms, but given their benefits to human health, many studies have aimed to enhance their accumulation in transgenic crops. Perilla frutescens (perilla) accumulates more ALA in its seed oil compared to other oilseed crops, making it a good candidate for the production of fatty acids via the fatty acid desaturase D6DES.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In this study, we cloned the D6DES gene from Phytophthora citrophthora and confirmed its function in budding yeast. We then transformed the functional D6DES gene under the control of the seed-specific vicilin promoter into the perilla cultivar Yeobsil. The resulting transgenic perilla seeds accumulated significant levels of GLA and SDA, as well as putative C18:2Δ</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Thus, PcD6DES perilla plants may represent a feasible alternative to traditional marine sources for the production of omega-3 oil capsules and to evening primrose seed oil for GLA as health food. In addition, these plants can be used to create other transgenic lines harboring additional genes to produce other desirable fish-oil like oils.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30935415</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2229</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>BMC plant biology</Title><ISOAbbreviation>BMC Plant Biol</ISOAbbreviation></Journal><ArticleTitle>High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds.</ArticleTitle><Pagination><MedlinePgn>120</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12870-019-1713-2</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Polyunsaturated fatty acids such as linoleic acid (LA) and α-linolenic acid (ALA) are abundant in vegetable oils and are important for human health. In the body, LA and ALA are respectively converted to the omega-6 fatty acid γ-linolenic acid (GLA) and the omega-3 fatty acid stearidonic acid (SDA) by Δ6 desaturase (D6DES). Currently, dietary GLA and SDA are mainly obtained from marine organisms, but given their benefits to human health, many studies have aimed to enhance their accumulation in transgenic crops. Perilla frutescens (perilla) accumulates more ALA in its seed oil compared to other oilseed crops, making it a good candidate for the production of fatty acids via the fatty acid desaturase D6DES.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In this study, we cloned the D6DES gene from Phytophthora citrophthora and confirmed its function in budding yeast. We then transformed the functional D6DES gene under the control of the seed-specific vicilin promoter into the perilla cultivar Yeobsil. The resulting transgenic perilla seeds accumulated significant levels of GLA and SDA, as well as putative C18:2Δ<sup>6,9</sup> at minor levels. Developing seeds and leaves also accumulated GLA and SDA, although PcD6DES expression and GLA and SDA levels were much lower in leaves compared to developing seeds. GLA and SDA accumulated in both polar lipids and neutral lipids in mature perilla seeds expressing PcD6DES, especially in neutral lipids. Although the seed weight in PcD6DES perilla was 87-96% that of wild type, the total oil content per seed weight was similar between lines. The PcD6DES perilla plants contained very high content (over 45%) of both GLA and SDA in seed oil.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Thus, PcD6DES perilla plants may represent a feasible alternative to traditional marine sources for the production of omega-3 oil capsules and to evening primrose seed oil for GLA as health food. In addition, these plants can be used to create other transgenic lines harboring additional genes to produce other desirable fish-oil like oils.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kyeong-Ryeol</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Kyung-Hwan</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea. biopiakim@korea.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jung Bong</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Agro-food Resources, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Seung-Bum</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biology, National Institute of Agricultural Science, RDA, Wanju-gun, Jeollabukdo, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Inhwa</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute of Agricultural Science, RDA, Jeonju, 54874, Jeollabukdo, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyun Uk</ForeName><Initials>HU</Initials><AffiliationInfo><Affiliation>Department of Bioindustry and Bioresource Engineering, Plant Engineering Research Institute, Sejong University, Seoul, 05006, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Myung Hee</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Southern Area Crop Science, National Institute of Crop Science, Miryang, Gyeongsangnamdo, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jae Kwang</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Division of Life Sciences, Incheon National University, Incheon, Republic of Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>PJ01257102</GrantID><Agency>Rural Development Administration</Agency><Country></Country></Grant><Grant><GrantID>NRF-2017R1A2B4007096</GrantID><Agency>National Research Foundation of Korea</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Plant Biol</MedlineTA><NlmUniqueID>100967807</NlmUniqueID><ISSNLinking>1471-2229</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010938">Plant Oils</NameOfSubstance></Chemical><Chemical><RegistryNumber>78YC2MAX4O</RegistryNumber><NameOfSubstance UI="D017965">gamma-Linolenic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>P4CEK3495O</RegistryNumber><NameOfSubstance UI="C062895">stearidonic acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015525" MajorTopicYN="N">Fatty Acids, Omega-3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031344" MajorTopicYN="N">Perilla frutescens</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010938" MajorTopicYN="N">Plant Oils</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017965" MajorTopicYN="N">gamma-Linolenic Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Delta 6 desaturase</Keyword><Keyword MajorTopicYN="N">Perilla</Keyword><Keyword MajorTopicYN="N">Phytophthora citrophthora</Keyword><Keyword MajorTopicYN="N">Stearidonic acid</Keyword><Keyword MajorTopicYN="N">γ-Linolenic acid</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId 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last="Kim">Hyun Uk Kim</name><name sortKey="Kim, Jae Kwang" sort="Kim, Jae Kwang" uniqKey="Kim J" first="Jae Kwang" last="Kim">Jae Kwang Kim</name><name sortKey="Kim, Jung Bong" sort="Kim, Jung Bong" uniqKey="Kim J" first="Jung Bong" last="Kim">Jung Bong Kim</name><name sortKey="Kim, Kyung Hwan" sort="Kim, Kyung Hwan" uniqKey="Kim K" first="Kyung-Hwan" last="Kim">Kyung-Hwan Kim</name><name sortKey="Lee, Myung Hee" sort="Lee, Myung Hee" uniqKey="Lee M" first="Myung Hee" last="Lee">Myung Hee Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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